Marine species represent a great source of biologically active substances; Actinia equina (AE), an Anthozoa Cnidaria belonging to the Actinidiae family, have been proposed as original food and have already been included in several cooking recipes in local Mediterranean shores, and endowed with excellent nutraceutical potential. The aim of this study was to investigate some unexplored features of AE, through analytical screening and an in-vitro and in-vivo model. An in-vitro study, made on RAW 264.7 stimulated with H2O2, showed that the pre-treatment with AE exerted an antioxidant action, reducing lipid peroxidation and up-regulating antioxidant enzymes. On the other hand, the in-vivo study over murine model demonstrated that the administration of AE extracts is able to reduce the carrageenan (CAR)-induced paw edema. Furthermore, the histological damage due to the neutrophil infiltration is prevented, and this highlights precious anti-inflammatory features of the interesting food-stu. Moreover, it was assessed that AE extract modulated nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) and The nuclear factor erythroid 2–related factor 2 (Nrf-2) pathways. In conclusion, our data demonstrated that thanks to the antioxidant and anti-inflammatory properties, AE extract could be used as a new food supplement for inflammatory pathology prevention.

Properties of a new food supplement containing actinia equina extract / Lanza, Marika; Casili, Giovanna; Torre, Giovanna Loredana La; Giuffrida, Daniele; Rotondo, Archimede; Esposito, Emanuela; Ardizzone, Alessio; Rando, Rossana; Bartolomeo, Giovanni; Albergamo, Ambrogina; Vadalà, Rossella; Salvo, Andrea; Lanza, Marika; Casili, Giovanna; Torre, Giovanna Loredana La; Giuffrida, Daniele; Rotondo, Archimede; Esposito, Emanuela; Ardizzone, Alessio; Rando, Rossana; Bartolomeo, Giovanni; Albergamo, Ambrogina; Vadalà, Rossella; Salvo, Andrea. - In: ANTIOXIDANTS. - ISSN 2076-3921. - 9:10(2020), pp. 1-22. [10.3390/antiox9100945]

Properties of a new food supplement containing actinia equina extract

Salvo, Andrea
Supervision
;
Salvo, Andrea
Supervision
2020

Abstract

Marine species represent a great source of biologically active substances; Actinia equina (AE), an Anthozoa Cnidaria belonging to the Actinidiae family, have been proposed as original food and have already been included in several cooking recipes in local Mediterranean shores, and endowed with excellent nutraceutical potential. The aim of this study was to investigate some unexplored features of AE, through analytical screening and an in-vitro and in-vivo model. An in-vitro study, made on RAW 264.7 stimulated with H2O2, showed that the pre-treatment with AE exerted an antioxidant action, reducing lipid peroxidation and up-regulating antioxidant enzymes. On the other hand, the in-vivo study over murine model demonstrated that the administration of AE extracts is able to reduce the carrageenan (CAR)-induced paw edema. Furthermore, the histological damage due to the neutrophil infiltration is prevented, and this highlights precious anti-inflammatory features of the interesting food-stu. Moreover, it was assessed that AE extract modulated nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) and The nuclear factor erythroid 2–related factor 2 (Nrf-2) pathways. In conclusion, our data demonstrated that thanks to the antioxidant and anti-inflammatory properties, AE extract could be used as a new food supplement for inflammatory pathology prevention.
2020
actinia equina; food supplement; marine resources; antioxidant; anti-inflammatory
01 Pubblicazione su rivista::01a Articolo in rivista
Properties of a new food supplement containing actinia equina extract / Lanza, Marika; Casili, Giovanna; Torre, Giovanna Loredana La; Giuffrida, Daniele; Rotondo, Archimede; Esposito, Emanuela; Ardizzone, Alessio; Rando, Rossana; Bartolomeo, Giovanni; Albergamo, Ambrogina; Vadalà, Rossella; Salvo, Andrea; Lanza, Marika; Casili, Giovanna; Torre, Giovanna Loredana La; Giuffrida, Daniele; Rotondo, Archimede; Esposito, Emanuela; Ardizzone, Alessio; Rando, Rossana; Bartolomeo, Giovanni; Albergamo, Ambrogina; Vadalà, Rossella; Salvo, Andrea. - In: ANTIOXIDANTS. - ISSN 2076-3921. - 9:10(2020), pp. 1-22. [10.3390/antiox9100945]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1441394
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